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Oxalate is a dicarboxylic acid composed of two carbon atoms and exits in solution as a dianion of the formula C 2 O 4 2 ( OOCCOO )
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[2] This is not an incidental formulation choice
Furthermore, heme can drive TNF-- and ROS-mediated necroptosis [225], heme oxygenase 1-dependent ferroptosis [226], and NLRP3 inflammasome-associated pyroptosis [227], which are highly proinflammatory RCDs
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