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conducted a retrospective cohort study and found that there was a significantly lower risk of HHF in patients with T2DM, overweight/obesity, and HFpEF receiving GLP-1 RA plus SGLT2i therapy compared with the SGLT2i-only therapy, suggesting a potential incremental benefit of GLP-1 RA [81]

However, current clinical trials have not shown a significant difference in side effect rates between GIPR/GLP-1R dual agonist and GLP-1RA alone

the other improves how remaining cells function

### **Dosing schedule and administration** Record the intended dosing schedule: a 30 mg subcutaneous injection (equivalent to 30 billing units of J0517) every 4 weeks for the first three doses, then every 8 weeks thereafter