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Unlike GHRP-2 and GHRP-6, which can elevate cortisol, prolactin, and acetylcholine levels, ipamorelin has been shown in animal studies to have no significant effect on adrenocorticotropic hormone (ACTH), cortisol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), or prolactin release
The supplements independent effectiveness without lifestyle changes is unclear
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