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To address these limitations, insulin analogs with modified amino acid sequences and structures have been developed, offering improved pharmacokinetic and pharmacodynamic profiles
The primary end point (a composite of cardiovascular death, myocardial infarction, or ischemic stroke) occurred in 613 patients in the saxagliptin group and in 609 patients in the placebo group (7.3 and 7.2%), which was not significantly different
From week five, the dose is usually increased to 0.5 mg weekly (8)
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