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in Value in Health modeled lifetime costs and quality-adjusted life years (QALYs) for three strategies: Indefinite semaglutide treatment 1-year treatment followed by discontinuation No pharmacotherapy (behavioral intervention only) For patients who lost 15%+ body weight on treatment, indefinite continuation was cost-effective at a willingness-to-pay threshold of $100,000 per QALY, primarily due to reduced diabetes and cardiovascular disease costs

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These studies indicated that VP1-001 also improved cataracts in human lenses ex vivo