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Barring any unforeseen complications, orforglipron is on track to be the next big new GLP-1 approval
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
Why should they care
Contact your GP immediately if you experience severe or persistent abdominal pain, signs of pancreatitis (intense upper abdominal pain radiating to the back with nausea), symptoms of gallbladder problems (upper right abdominal pain, jaundice, fever), persistent vomiting preventing adequate hydration, or if side effects significantly impact your quality of life despite management strategies
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