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Robert Siegel, director of Cincinnati Childrens Center for Better Health and Nutrition, tells TODAY.com

In tirzepatide research, these events are typically mild to moderate and diminish over time as the subject acclimates to the compound

tirzepatide , the core difference lies in how many targets each drug hits: Tirzepatide (Mounjaro): A dual agonist that activates GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) receptors