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13 NONCLINICAL TOXICOLOGY NONCLINICAL TOXICOLOGY SECTION 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY SECTION A 2-year carcinogenicity study was conducted with tirzepatide in male and female rats at doses of 0.15, 0.50, and 1.5 mg/kg (0.1-, 0.4-, and 1-fold the MRHD of 15 mg once weekly based on AUC) administered by subcutaneous injection twice weekly
Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al
However, in 2024 Eli Lilly spent $2.5 billion on share repurchases and increased its quarterly dividend by 15%
Safety considerations warrant discussion , particularly regarding gastrointestinal side effects that might affect medication adherence or nutritional status
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