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37 , 355.e21355.e29 (2019)

Insulin resistance and blood sugar imbalance occur in the development of type 2 diabetes , and may be associated with a defect in fatty-acid metabolism in muscle and tissue lipid (fat) accumulation

BalogunEHoqueMGongPKilleenEGreenCJForestiRet al

Western blots suggest that the reduced cleavage by X(PC5) variants likely stems from lower expression and stability of the proteases in mammalian cells (Fig