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Yes, continuous exposure can desensitize surface receptors, so most protocols incorporate "on" and "off" cycles to maintain biological response and prevent antibody buildup
Effects on the digestive system During treatment with this medicine, you may feel sick (nausea) or be sick (vomiting), or have diarrhoea
USA 98 , 1281412819 (2001)
A gradual climb from the starting dose to the maximum therapeutic dose
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