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Following the transfer of aminopropyl groups, dcSAM transforms into 5-deoxy-5-methylthioadenosine, which then can undergo a series of steps in the Met salvage pathway to regenerate adenine and Met (Lauinger and Kaiser, 2021)
The specific criteria vary by indication: For T2D (Ozempic/Mounjaro): Documented T2D diagnosis, HbA1c at or above 7%, prior treatment history (typically metformin unless contraindicated), and prescriber documentation of clinical management
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