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As it drops during perimenopause the body shifts toward visceral storage

Key findings include: Interaction with NRF2 transcription factor to activate stress-response pathways Upregulation of genes involved in glucose restriction responses Enhanced expression of antioxidant and cytoprotective genes Regulation of heat shock response proteins This nuclear regulatory function occurs within 30 minutes of metabolic stress exposure and represents a novel mechanism of mitochondrial-to-nuclear retrograde signaling

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