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doi: 10.3389/fnins.2026.1736978 Received 31 October 2025 Revised 24 January 2026 Accepted 03 February 2026 Published 04 March 2026 Volume 20 - 2026 Edited by Charles N
Since we have now shown that the 1st glutathione-interaction site can serve not only as a scaffold site for GSSR substrates but also as an activator site for GSH for the reduction of non-glutathione disulfide substrates, we would like to suggest to preferably use the terms 1st and 2nd glutathione-interaction site (e.g., in combination with the function as a scaffold or activator) to avoid ambiguities in the future
Any recommendation for treatment or prevention of constipation should be based on the totality of the clinical evidence
& Okuno, Y
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