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These hemodynamic interactions are not reflected in current prescribing information for tirzepatide, not because they have been evaluated and found absent, but because patients with hEDS and POTS were not systematically enrolled in the pivotal SURMOUNT trials, which excluded individuals with significant cardiovascular, renal, and neurological comorbidities

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Thats what happened to Beccarelli, who gradually gained more than 25 pounds while taking a hormone blocker

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