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The Phase 3 SYNERGY trial (NCT06859268) will evaluate whether retatrutide can resolve steatohepatitis (liver inflammation) and fibrosis, endpoints that would be required for regulatory approval specifically for liver disease treatment
Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation
This study demonstrated that speeding up acetaldehyde clearance by preserving ALDH2 activity critically mediates the beneficial effect of MitoQ on alcohol-induced pathogenesis at the gut-liver axis.[ref] Zinc and niacin (vitamin B3) are both cofactors for acetaldehyde dehydrogenase.[ref] Make sure you have sufficient levels of both through foods or supplements
