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The perceived energy boost reported by non-deficient individuals is likely attributable to placebo effect

Aromatase converts testosterone to estradiol (estrogen), creating a vicious cycle where increasing belly fat leads to lower testosterone, which in turn promotes more fat storage

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Mechanisms such as cellular senescence, genomic instability, telomere attrition, mitochondrial dysfunction, epigenetic alterations, and loss of proteostasis all contribute to an aging phenotype (Tenchov et al 2024) and are considered hallmarks or biomarkers for aging