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Preclinical Pharmacology Comprehensive preclinical studies in diet-induced obese mice, diabetic mouse models, and non-human primates established the pharmacological proof of concept
Chronological (Intrinsic) Aging Intrinsic or chronological aging is a natural process with the passage of time that causes inflammation with the production of reactive oxygen species (ROS) resulting in oxidative stress from cellular metabolism, which results in a loss of skin homeostasis [9, 10, 14] (Fig
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