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Recent clinical trials have shown that coagonists induce significant benefits on body weight, fasting, and postprandial glucose levels, insulin sensitivity, and total cholesterol
The result is often worse nausea, bloating, and discomfort than either the injection alone or the food alone would have caused
Triglycerides should improve
Metformin, the first-line treatment for T2D, induces vitamin B12 deficiency through calcium-dependent antagonism of the intrinsic factor-B12 complex absorption in the terminal ileum, with studies showing a 13% increased risk of deficiency per year of use and higher prevalence in patients using metformin for more than 4 years at doses exceeding 1000 mg daily [158]
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