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The later may be clinically important in a situation where we encounter a patient with T2DM and a failed previous revasc attempt, who are both less attractive to offer a new lower limb procedure to from the clinicians point of view, and (sometimes) also not desirable from the patients own perspective.
That does not make the compound meaningless
Known for containing the same active ingredient found in medications like Wegovy and Ozempic, semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that has revolutionized weight management
Although these agents reliably reduce weight and fat mass in patients with T2D, their effects in normoglycaemic PD populations appear less pronounced [12, 13, 31,32,33,34]
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