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Usually decreases with continued use
4 MCR Target receptors MC1R, MC3R, MC4R, MC5R activated simultaneously
To decrease the potential unwanted side effects, in this study, the local delivery strategy, including topical delivery for skin hyperpigmentation and peritumoral injection for skin tumors, is adopted to minimize the systemic exposure
To further determine the importance of the PI3K/AKT signaling in NAC-modulated function, TSPCs were treated with, or without, NAC in the presence or absence of an PI3K/AKT inhibitor (LY294002), and the relative levels of PI3K/AKT phosphorylation and integrin 51 expression were analyzed by Western blotting
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