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Abrupt cessation without any replacement strategy is the highest-risk scenario for rapid rebound
Phase 3 TRIUMPH-4 results announced by Eli Lilly in December 2025 reported average weight loss of 71.2 lbs alongside significant relief from osteoarthritis pain, confirming that the Phase 2 efficacy signal translates to large-scale Phase 3 populations
Some physicians actually prefer that their patients remain on bupropion during tirzepatide treatment because the dopaminergic support helps maintain motivation and prevents the emotional eating rebound that can sabotage weight loss efforts
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