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GLP-1 exerts anti-inflammatory effects by suppressing the NF-B signaling pathway, which leads to a decrease in the production of pro-inflammatory cytokines like TNF- and IL-6, thereby mitigating liver inflammation and fibrosis

To the best of our knowledge, the present study is the first prospective study to show that 1,800 mg/day L-carnitine supplementation for 6 months exhibited favorable effects on chronic fatigue in patients with cirrhosis

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Side effect comparison: Nausea: Similar rates between the two compounds Vomiting: Cagrilintide significantly lower (OR 0.38) Diarrhea: Comparable rates Constipation: Similar Injection site reactions: Cagrilintide substantially higher Discontinuation due to AEs: Cagrilintide much lower (1% vs approximately 5-7%) The takeaway: if vomiting was your main problem on semaglutide, cagrilintide may be worth exploring