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During the nose-to-brain delivery, some molecules can be delivered to undesirable regions and cause serious problems because nasally administered drugs can be distributed to both systemic and brain compartments

Unfortunately, the classification does not allow an accurate separation between morphological changes (e.g

This process releases the inhibition on the NF-B (RelA/p50) dimer, exposing the nuclear localization signal (NLS) of the RelA/p50 dimer and driving its nuclear translocation