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Supporting the overall concept of enzymatic degradation of IgG, the Fc-fused pan-IgG protease S-1117 displays therapeutic efficacy in a mouse model of ITP [417]
Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1
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Further, we found that HCC patients with high serum and tissue AFP, a marker of aggressive disease, exhibit lower GSH abundance in their tumor tissues than patients with low AFP (Fig 4E and F)
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