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This is true for everyone but it is especially critical for people on GLP-1 drugs, because these medications reduce appetite and total food intake

Given that both of these studies were in patients with OA of the knee (a load-bearing joint), it is likely that a significant proportion of the efficacy observed was due to the significant loss of body weight, reducing pathological joint loading

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Discuss your complete medical history, including any history of diabetes, pancreatitis, thyroid disorders, or gastrointestinal disease