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At present, even though the comparative efficacy of tirzepatide vs these higher dosing regimens of dulaglutide and semaglutide is unknown, available data suggest that tirzepatide could be a reasonable treatment option when glycaemic control and body weight loss are therapeutic priorities
You can point out that in Canada, over 30% of the adult population has a BMI over 30 and a significant percentage will have BMIs greater than 27 and with weight responsive medical conditions
Experimental studies have demonstrated that metformin induces a modest but functionally meaningful inhibition of mitochondrial respiratory activity, thereby constraining oxidative metabolism and limiting gluconeogenic flux [8,37,48]
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