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They also reported that no weight loss medication use was associated with a decreased risk at a follow-up of five years (RR, 0.47), seven years (RR, 0.52), and 10 years (RR, 0.52) compared with OWLD use
Preclinical models suggest it may help stabilize liver clock genes, particularly through interaction with CRY1, a core circadian regulator (Bian et al., 2022)
Management: Limit use to 46 week cycles with at least equal time off Consider using GH peptides like GHRP2 or CJC1295 during off cycles to maintain baseline IGF-1 activity Risk of Unwanted Growth (Organs, Gut, Tumors) Long-term, excessive IGF1 can theoretically increase the risk of visceral organ growth , insulin resistance , or even tumor promotion , due to its role in cell proliferation
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