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The signal for acute kidney injury (675 cases) was more prominent in elderly and overweight groups, potentially linked to metformins contraindication in renal impairment 34 and the dehydration effects of GLP-1RAs 40 , highlighting the need for strict baseline renal function screening and monitoring of blood volume status

Briefly, FLS were seeded on glass slides, washed twice with D-Hanks, fixed with 4% paraformaldehyde, and then permeabilized with 0.2% Triton X-100

The takeaway is to know the symptom, not to add a monthly test

Participants will be randomized to receive either tirzepatide or a placebo by mail and will take it for a year