GLP-1 receptors are expressed in cardiovascular tissues, which may contribute to cardiovascular effects, though it should be noted that while some selective GLP-1 receptor agonists have demonstrated cardiovascular benefits in outcome trials, definitive cardiovascular outcome data for tirzepatide are still awaited
Starting doses are typically lower in post-surgical patients to allow the digestive system to adapt without overwhelming existing bile reflux or motility issues
7,9,13-15 Because weight loss improves insulin resistance, hypertension, dyslipidemia, stroke, cardiovascular disease, sleep apnea, osteoarthritis, gallbladder disease, and certain cancers (e.g., breast, colorectal, endometrial, gallbladder), it is important to alert women who are prescribed these drugs to the potential for weight gain, especially during the MT
This is also the behavior we obtain with the hinge-latch model, but not with the dissociation model