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No one should be taking these medicines without the guidance of a physician or other good providers, says Spencer Nadolsky, DO, the physician-founder of Vineyard.com, which abides by FDA criteria for prescribing GLP-1s, and offers access to registered dietitians and a strength coach

But within those calories, protein is the single most important macronutrient for semaglutide users

One small nondiabetic study showed a 6.5% weight loss with sitagliptin versus 7.65% with metformin, but larger studies in T2DM have not confirmed a direct effect on weight

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