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In addition, there is a high predisposition of the councils with this AEHVE action, as demonstrated by the high number of cities involved to #HepCityFree
Each estimand carries its own placebo comparator 2.3% under the trial product estimand, 3.0% under treatment policy so the placebo arm moves in the opposite direction to the treatment arm between the two analyses
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The overall discontinuation rate was 4.3% to 7.1% (Jastreboff et al., NEJM 2022)
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