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Persistent vomiting requiring medical intervention affected approximately 2-3% of patients

However, therapeutic doses for treating deficiency and associated nerve damage are substantially higher

doi:10.1126/science.125.3253.884

After four weeks, those treated with Pycnogenol, at dosages of either 150 mg or 100 mg daily, had increased cochlear blood flow in the affected ear and reduced tinnitus severity, and the effects were more pronounced in those receiving the higher dosage