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Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of -amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling

Dados toxicolgicos pr-clnicos: Os estudos de toxicidade aguda e subaguda em ratos no evidenciaram mortalidade nem toxicidade orgnica significativa, mesmo em doses amplamente superiores s doses teraputicas (at 100 vezes a dose eficaz)