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For example, the nanoparticle NanoMnSor composed of a MnO 2 core and lipid and loaded PLGA with sorafenib can co-deliver sorafenib and MnO 2, where MnO 2 can reduce hypoxia by reacting with H 2 O 2 produced by overactive metabolism of tumor cells and H + in acidic TME to produce oxygen, which can not only overcome resistance to sorafenib but also promote macrophage polarization towards the immune-stimulated M1 phenotype (61)

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