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In the phase 2 NEJM trial, participants receiving the highest dose of retatrutide (12 mg) achieved a mean body weight reduction of approximately 24.2% from baseline at 48 weeks, compared with approximately 2.1% in the placebo group
Shared effects include: Nausea Vomiting Diarrhea Constipation Reduced appetite Mild fatigue Clinical trials consistently show mostly mild-to-moderate gastrointestinal side effects with both medications, with nausea being the most commonly reported symptom
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