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These patients continue twice-weekly dosing long-term, often because they believe it is working better, even when objective outcomes (weight loss, A1c reduction) are identical to weekly dosing

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Insulin-like growth factor 1 (IGF1) is a key growth factor that increases protein synthesis via the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway (Yoshida and Delafontaine, 2020)

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