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Despite their promise, the hydrophobic nature of certain carriers may lead to premature drug release, which can be mitigated by PEG modification or hydrophilic coatings [131]
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The latter enzyme is expressed in all human cells that contain a mitochondria except for hepatocytes
Since 2015, the humanized anti-CD22 monoclonal antibody epratuzumab has been investigated for the treatment of SLE, holding promise for patients with moderate to severe active disease (142144)
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