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Source: Arrone, et al New England J of Medicine May 11, 2025 Researchers randomized about 1,500 people with obesity and without diabetes to be treated with either tirzepatide or semaglutide, both at the highest tolerable recommended doses, and followed them for 72 weeks
Participants were divided into those receiving concurrent hormone therapy and those who were not, with groups carefully matched by age, BMI, and clinical history to reduce the most obvious confounding variables
Biochem J, 2005
The medication's effect on satiety and food intake diminishes over time, which may lead to increased hunger and potential weight regain
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