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A rough rule: if your scale weight is dropping faster than 1 percent of body weight per week over multiple weeks, investigate whether protein intake and training volume are adequate before concluding that faster is better

10.1111/j.1742-4658.2006.05548.x FEBS J

Large-scale randomized controlled trials, including the SUSTAIN and STEP trial programs involving thousands of participants, have not identified immunosuppression as an adverse effect of semaglutide therapy

This article covers the clinical dosing limits of semaglutide, the risks of exceeding recommended amounts, and how a personalized program can help you overcome weight loss stalls safely