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For moderate to severe RLS that significantly impacts quality of life, UK guidelines suggest dopamine agonists (such as pramipexole, ropinirole, or rotigotine) or gabapentinoids (gabapentin or pregabalin) may be considered as first-line pharmacological treatments under specialist guidance

black pepper fruit extract (Piper Nigrum L.) 95% piperine, capsule shell (gelatin, water, colours: titanium dioxide, iron oxide red, allura red AC*, cochineal red A*, quinoline yellow*), chromium picolinate (chromium)

Recent research from Oxford confirms that patients who combine GLP-1 medications with lasting lifestyle changes have the best long-term outcomes

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