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These medications are not recommended during pregnancy or breastfeeding, and caution is needed in patients with a history of pancreatitis
How GLP-1s Work Mechanism: Mimic or enhance incretin hormones (GLP-1) to reduce appetite , slow gastric emptying , improve insulin secretion , and lower blood glucose
Data are in line with results in randomised controlled trials and show the long-term stable benefit of once weekly semaglutide, Karasik said.
But the FDAs decision signals a turning point for broader Medicare coverage of GLP-1s since Wegovy can now be used to reduce the risk of heart attack and stroke by people with cardiovascular disease and obesity or overweight, and not only as an anti-obesity drug
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