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They are: Vitamin B1 Vitamin B2 Vitamin B6 Vitamin B12 Vitamin B9 Zinc Magnesium Selenium Vitamin E Vitamin C Alpha lipoic acid These vitamins, minerals and antioxidants play a number of roles: They trigger the glutathione enzymatic system They enable glutathione production by directing cysteine, and increasing cellular uptake of cysteine They participate in the formation of glutathione from its precursor amino acids They help reactivate glutathione, transitioning it from its oxidized state back to its active state They maintain the balance of oxidized and active glutathione They are in turn activated by glutathione and each other, allowing for a robust presence of antioxidants Without these 11 cofactors, glutathione would not be as plentiful, as active, or as efficacious