weight regain after tirzepatide Rebound gain stopping semaglutide or is real, but it's not because the body is “damaged”—it reflects how the body adapts after weight loss. When the medication is stopped, hunger Weight Regain After Tirzepatide: Prevention

doi: 10.3390/nu11051136

Results Over a median follow-up of four years, the primary composite outcome occurred in 12.2 percent of the tirzepatide group and 13.1 percent of the dulaglutide group

Research mechanism GLP-1 receptor activation in pancreatic -cells, hypothalamus, brainstem Glucose-dependent insulin secretion Delayed gastric emptying Central appetite suppression via hypothalamic and brainstem receptors Trial data summary STEP 1 trial (Wilding et al., NEJM 2021): mean body weight reduction of 14.9% at 68 weeks with weekly 2.4mg dosing

If you choose to use one of these medications for the long term in order to help control your blood sugar or maintain your weight loss, this is generally considered to be a safe option