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If youve tried B12 shots elsewhere and felt nothing, theres a real chance you got cyanocobalamin and a real chance methylcobalamin will feel different

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Topical Administration (Most Common) The most widely used approach is topical application via DMSO (dimethyl sulfoxide): Dissolve 3-5mg Dihexa in a few drops of DMSO Apply to forearm skin (DMSO acts as a carrier to drive the peptide through the skin) DMSO concentration: ~20-30% in the solution Pros: Effective absorption, avoids injection Cons: DMSO has a strong garlic-like odor that can transfer to breath/skin Starting Dose Begin at 1-3mg topically to assess response Work up to 3-5mg if tolerating well Cycling Protocol Dihexa appears to have lasting effects that persist after stopping likely due to synaptogenesis (new connections don't disappear when you stop)

[PubMed] [PMC] Biasibetti R, Almeida Dos Santos JP, Rodrigues L, Wartchow KM, Suardi LZ, Nardin P, Selistre NG, Vzquez D, Gonalves C-A (2017) Hippocampal changes in STZ-model of Alzheimers disease are dependent on sex