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Some gastroenterologists have noted reports of ischemic colitisreduced blood flow to the colonin patients taking GLP-1 agonists, potentially related to altered gut motility or other mechanisms

10.2337/diacare.28.5.1083 35 KimT

Evidence for epigenetic regulation of gene expression and function in chronic experimental diabetic neuropathy

Long-term users often report better energy than before treatment due to benefits of weight loss including improved sleep, reduced joint pain, better fitness, and improved metabolic health