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Periodic body composition assessment with DXA or bioelectrical impedance helps track changes in lean mass versus fat mass and guides adjustments to diet, protein targets, and resistance training

However, the protective effect was strongest in patients with obesity and absent in non-obese patients, strongly suggesting that benefits are heavily confounded by weight loss and metabolic improvement rather than direct gut anti-inflammation (101)

We have a program in MASH, in the liver, the LIVERAGE program, plus a robust data-generation program to come over the next couple of years, because we want to bring a comprehensive package for metabolic health, said Neeraja Balachander, who oversees the companys cardio-renal-metabolic portfolio

Despite this long clinical history, widespread public awareness only emerged recently due to expanded weight-loss applications and celebrity discussions, creating the illusion that these are brand-new treatments rather than established medications with proven track records