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EA-induced phosphorylation of AMPK and inhibition of mTOR facilitated the upregulation of autophagy-related proteins such as LC3-II and Beclin-1, as well as enhanced autophagosome formation observed by transmission electron microscopy ( Collectively, these data suggest that EA exerts a therapeutic role in MASLD not only by correcting metabolic derangements, but also by orchestrating a complex interplay between inflammatory suppression, fibrosis attenuation, and autophagy recovery

[30] The ferritin storage iron pool is much larger than the labile iron pool, ranging in concentration from 0.7 mM to 3.6 mM

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