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Preclinical studies have examined cagrilintide as a non-selective agonist of the amylin receptors (AMY1R, AMY2R, AMY3R) and the calcitonin receptor, with reported activity in the area postrema and hypothalamus relevant to appetite regulation and satiety signalling

252 The NICD then translocates into the nucleus, where it forms a transcriptional complex with RBP-J and Mastermind-like (MAML) coactivators, activating downstream targets such as Hes, Hey, c-Myc, and Bcl-2

Cordes, N., Blaese, M

These probes, when activated by nitroreductase and NADH, demonstrated efficient and selective release of fluorescent molecules such as Nile Blue or resorufin 127,128