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269,270 An imbalance between mitochondrial biogenesis and fission leads to the formation of small, dysfunctional mitochondria, affecting both neurons and Schwann cells and exacerbating peripheral nerve damage

Avoid temptation increasing dose or frequency thinking "more is better." Stable effective protocol through completion then reassess need for continued treatment versus tapering

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Even if the most likely explanation is a known medication effect, ruling out other causes is important