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Selenocysteine utilization by GPX4 confers exquisite resistance to irreversible overoxidation as cells expressing a cysteine variant are highly sensitive to peroxide-induced ferroptosis [35]

Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells

In adipose tissue, elevated NNMT activity is strongly correlated with obesity, insulin resistance, and cellular aging